- About NPs, CNPs & Nanobacteria

My "White Paper" posted in "The Heart" at American Heart Association website........
The Cause of Coronary Artery Calcification and it's role in development of Vulnerable Plaque - Gary S. Mezo
Coronary Artery Calcification (CAC) is secondary to an infection by CNPs (CNPs were formerly known as Nanobacteria). CNPs also cause inflammation from their exudate, a LPS Biofilm. CNPs use (oxidize) LDL in their regeneration-cycle. CNPs have 2 pleomorphic modes of growth: fast (replication every 3 days) which involves LPS Biofilm; and slow (replication every 6 days) which involves development of calcium "igloos" around themselves. CNPs, when locked in the intimal-medial space, will be temporarily deprived of their "foodstuff" which is VLDL/LDL from serum/blood. In this mode, CNPs calcify upon themselves, building an intimal-medial "coral-reef" bolus of calcification. As our immune system tries to wall-off the area (like a cyst) , the area is covered with amyloid-like soft plaque. This stabilizes the lesion....but only temporarily. After a while, our immune system recognizes the area as "stable" and does what it normally does to a walled-off area of infection....it tends to regenerate and debulk the area....by initiating the process of neovascularization. In the process of neovascularization----fresh blood containing VLDL & LDL is supplied to the area. Now the CNPs have their required nutrients of lipids. This causes the CNPs to switch to fast replication and form their LPS biofilm....this causes our inflammation and swelling and our immune system is now fighting the infection...this is the "vulnerable plaque" phase. This process waxes and wanes until such time that the calcified plaque burden is so large that it can inflame the area, impair bloodflow and rupture into the lumen. CNPs then bind prothrombin and cause a clotting cascade....this leads to MI. We at NanoBiotech Pharma have developed therapeutics (NanobacTX) to reverse CNP infection & calcification. Author's disclosure (Jan 18, 2012) - Our researchers discovered CNPs and we direct CNP research Worldwide.

The pathogen, (NPs, CNPs & Nanobacteria) was originally filed as NANOBACTERIUM SANGUINEUM (latin for: Blood Nanobacteria), also referred to as Nanobacteria, Nb, CNPs and NPs. Since 2006, research has been categorizing the pathogen as a novel (unique) non-bacterial, non-viral, non-prion infectious agent either called Calcifying Nanoparticles (CNPs) or Nanoparticles (NPs), depending upon the particular researchers. Mayo Clinic researchers call them CNPs or NPs. NPs are not alive, at least not by the current strict microbiology definition of "living"......YET, They do self-reproduce and are actively involved in the development of the top diseases that threaten our health and kill us.....So, although they may be nano-small, they are a VERY big deal. The IP and R&D on Nanobacteria, CNP, NP is essentially owned by us.....the medical implications are huge and institution of our discoveries is disruptive to the current status-quo of medical pathophysiology knowledge and therapeutics. Why are we not already "Mainstream Medicine"? FACT: New/disruptive medical technologies are very slowly adopted into mainstream medicine and the average time for a new medical discovery to be adopted is 20 years.
SIZE: 25-200 NANOMETERS, Smallest known self-replicating entity. Proposed as a newly-discovered form of life/entity as an infectious agent. Smaller than current size standards for living entities, yet appear to cause life-long infections and disease in humans and other mammals. (Of note: Viruses and Prions are also not considered as living entities, yet their disease-causing behavior is well-known & documented). NPs cannot be seen using regular laboratory light microscopes and therefore have escaped scientific description and clinical detection until discovered in 1988. (They can only be seen under electron microscopes, atomic force microscopes and more recently using the revolutionary CytoViva Imaging system).
GROW VERY SLOWLY, replicating every 3-6 days instead of seconds or minutes.
VERY TOUGH TO KILL In Vivo & In Vitro, are extremely resistant to destruction, including: penicillins, cephalosporins, macrolides, heat, freezing, nanocolloidal silver & radiation. They easily circumvent & defeat our immune defense systems. They cause apoptosis (cell death) and alter RNA & DNA replication.
NPs appear to be the active cause of pathological extraskeletal calcification: They are pleomorphic and have several lifestyles: a calcific semi-dormant form and a slimy biofilm form. They form a calcium apatite lipopolysaccaharide (LPS) biofilm endotoxin that causes inflammation & tissue swelling, apoptosis & thrombus formation.
They are safely and effectively eliminated from different tissues by our nanobiotics: NanobacTX, Urobac & Dermabac.

HISTORY: CNPs/NPs were originally called Nanobacteria and were discovered in 1998 by our researcher and Nobel Prize Nominee Olavi Kajander, MD, PhD as a “contaminant” in mammalian cell cultures that kept killing the mammalian cells (apoptosis) in his cell culture research.

"The term “Nanobacteria" is short for it’s scientific genus & species name "Nanobacterium sanguineum", a Latin scientific term for blood nanobacteria. Nanobacteria are “nano”-sized in that they are from 25-200 nanometers in size (a nanometer is 1 billionth of a meter. A nanometer is the width of ten hydrogen atoms side-to-side!) and are the smallest known self-replicating entity.

Their nanometer-size and calcium component allows them to "trick" our cellular defense mechanisms, moving through cell walls to directly infect the nucleus of our cells and affect/alter RNA/DNA processes. They cause apoptosis (cell death) when exposed to the nucleus of cells in human cells, mammalian cells and other bacteria. While in a cell nucleus, they alter RNA and DNA gene-expression patterns......this leads apoptosis, genetic alteration of the cell, abnormal cell growth, excess cell proliferation and in cases, cancer.

When compared to bacteria, they grow very, very slowly, only reproducing every 3 to 6 days…..where bacteria reproduce in minutes or hours. They cannot be grown in standard culture media and can only be cultured (grown) in mammalian blood or serum. Their pleomorphism in human appears to vary, based upon their direct environmental availability of certain blood and serum components. When these environmental serum/blood components are restricted by location (infection sites, cysts, joints, scarring, kidneys & areas of hypovascular bloodflow) they exist in a semi-dormant mode, forming calcification deposits in a "budding" type of replication in that tissue. When certain needed/desired serum/blood components become available....they switch to their LPS Biofilm Endotoxin form and use a fission-type of replication. Documented by our researchers, they have a novel helical-form double-wall cell membrane not seen in any other life-form.

Infection by NPs is an “emerging infectious disease” meaning that it is recently discovered and that it's involvement & the diseases it cause are still being researched and described. CNPs/Nanobacteria require BSL-3-level containment in research facilities. DNA, RNA and LPS profiles have been accurately mapped by multiple scientific researchers at many universities worldwide. NPs have no known positive benefits to humans.

NPs utilize serum calcium and LDL to manufacture pathological calcification deposits under normal serum/blood calcium conditions. Until NPs, science has not been able to explain or show how such calcification is possible. Previously, scientists just accepted the unexplainable disease-related calcification development in our bodies as a mysterious unknown phenomenon of aging!

Aside from being toxic on its own, NP's calcium phosphate slimy endotoxin biofilm layer actively binds other proteins that are involved in many diseases and directly cause blood clotting (thrombosis).

NPs have been detected in urine and kidney stones, bile and gall bladder stones, atherosclerotic plaques, cataracts, MS, Alzheimer's, heart valves, polycystic kidney disease cysts, PKD, liver cysts, fetal bovine serum, viral vaccines, cancer, prostate stones, testicular stones, BPH, prostatitis, eczema, psoriasis, scleroderma, atopic dermatitis and many others......causing many researchers to believe today that all pathological calcification is secondary to these NPs....wherever they are found in the body.

NPs directly cause or participate in many pathological events such as inflammation in endovascular intimal-medial space neovascularization, thrombosis, autoimmune response, inflammation & cell proliferation, altered cell functions, pathological calcification, apoptosis (cell death) and tissue atrophy.

Mayo Clinic's Cardiovascular, Infectious Disease & Nephrology research team has shown in many published research papers that NPs play an active role in the development of arteriosclerosis and cardiovascular diseases such as coronary artery disease, heart valve calcification, kidney stones, PKD and many other diseases previously described as idiopathic (of unknown or unexplainable origin).......now attributed to NPs.

Stephen Epstein, MD, PhD (Former NIH Cardiovascular Research Director) at Washington Hospital Center in DC showed that antibodies against NPs are the highest known risk factor for coronary artery calcification and heart disease and the best predictor for risk of having a future heart attack (higher than HDL, LDL or Homocystiene).

Cleveland Clinic's Daniel Shoskes, MD, PhD as well as UCSF, Baylor and NASA Researchers showed NPs involvement in Prostate Disease, BPH & Kidney Stones. Scores of scientific papers have been published on NPs and their involvement in multiple diseases by our broad global network of collaborating researchers.....